Dense Breast Tissue Promotes Aggressive Cancers

�New enquiry may explain why breast cancer tends to be more aggressive in women with denser breast tissue.



Breast cancer cells grown in dense, stiff surroundings footprint up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 progeny of Current Biology.



The findings suggest a cellular mechanism for the correlation betwixt human breast tissue density and tumor aggressiveness. Women with increased breast concentration on mammograms have an increased risk for both developing breast cancer and having bosom cancers with invasive characteristics.



This connection between breast denseness and genus Cancer aggressiveness has begged the question of which comes first. Is the tissue paper denser because the tumor is more aggressive (and recruits cells that "lay down" more matrix), or is the tumor more aggressive because the tissue is denser?



"Our study shows that if you give birth a dense, rigid matrix, the cells will be more aggressive and invasive; it's a direct upshot," said Alissa Weaver, M.D., Ph.D., assistant professor of Cancer Biology and lead author of the study.



Weaver and colleagues were interested in invadopodia - the finger-like protrusions that a cancer cell uses to drill holes in the extracellular intercellular substance (matrix-degrading enzymes are associated with invadopodia). These structures are believed to be important for cancer invasion.



"If you have enough invadopodia, over time they'll make large holes that cells can move through to invade and metastasize," Weaver said.



Despite the intimate connection between invadopodia and the matrix, selfsame little was known about what theatrical role the matrix might play in regulation invadopodia subroutine. Weaver and colleagues started probing this question as part of computational math modeling project through the Vanderbilt Integrative Cancer Biology Center.



They were surprised to find that breast cancer cells cultured on a denser - and hence, more stiff - matrix had a greater number of active invadopodia than breast cancer cells civilized on a less thick matrix.



"We intellection that more 'stuff' for the cells to let through was going to make it harder, so we expected to envision less matrix degradation, only instead we found this interesting effect where cells actually sense the inflexibility and put down more," Weaver said.



The team examined how cells exchange a sense of matrix rigidity into intracellular signals, a treat called mechanotransduction.



Proteins that generate contractile forces, such as myosin "motors," are important players in mechanotransduction. Weaver and colleagues confirmed that myosin motors are involved in sparking more degradation by invadopodia in response to a rigid matrix, though the motors themselves are non present in the boring structures.



The investigators also concerned the activities of two signaling proteins called FAK and p130Cas in the rigidity-induced invadopodia activity. These signaling proteins were present in an activated state of matter in the invadopodia, suggesting that they are of import players in this reply and english hawthorn represent targets for anti-invasive therapies.



Weaver aforementioned that it's exciting to find a cellular mechanics that could explain why denser bosom tissue is correlated with more strong-growing tumors and a poorer prognosis for patients.



"The estimate that tissue paper rigidity leads to a more aggressive phenotype had been out there for a while," she aforesaid, "but it hadn't actually been tied to matrix degradation, which is thought to be important for metastasis and spread of cells through the body."



Because metastasis is often what makes cancers deadly, new leads on how to block it are vital, she added.





Nelson Alexander, Ph.D., Kevin Branch, Aron Parekh, Ph.D., Emily Clark, Ph.D., and Izuchukwu Iwueke, in the Department of Cancer Biology at Vanderbilt, and Scott Guelcher, Ph.D., in the Department of Chemical Engineering at Vanderbilt, contributed to the studies. The National Institutes of Health and the Vanderbilt University School of Engineering supported the research.



Source: Dagny Stuart McMillin

Vanderbilt University Medical Center




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Acid Mothers Temple

   
Artist: Acid Mothers Temple

   Genre(s): 
Rock: Electronic
   Pop
   

---

Discography:


   
 Mantra Of Love

   Year: 2004   
Tracks: 2


   
 Univers Zen ou de Zero a Zero

   Year: 2002   
Tracks: 6


   
 St Captain frak out....

   Year: 2002   
Tracks: 12


   
 In

   Year: 2002   
Tracks: 3


   
 Electric Heavyland

   Year: 2002   
Tracks: 3


   
 41st Century splendid man

   Year: 2002   
Tracks: 3


   
 New Geocentric world of ...

   Year: 2001   
Tracks: 7


   
 Absolutely freak out

   Year: 2001   
Tracks: 4


   
 Monster of the universe

   Year: 2000   
Tracks: 4


   
 La novia

   Year: 2000   
Tracks: 3


   
 Born to Be Wild in the USA 2000

   Year: 2000   
Tracks: 5


   
 Wild gails a go-go

   Year: 1999   
Tracks: 7


   
 Pataphisical freak out

   Year: 1999   
Tracks: 4


   
 Acid Mothers Temple and The Melting Paraiso UFO

   Year:    
Tracks: 1

---

After playing with such bands as Toho Sara, Ohkami No Jikan, Musica Transonic, and Mainliner, Japanese guitarist Makoto Kawabata distinct to proceed his musical explorations by bringing together likeminded individuals to create trippy psychedelic freak-outs inspired by Karlheinz Stockhausen, Krautrock, and '70s progressive hard rock. Acid Mothers Temple & the Melting Paraiso U.F.O. (Underground Freak Out) was founded in 1996 as a "soul corporate." It's not a commune in the full sense since the members don't all live together, just it is based on communal values and has fifty-fifty been misguided by some people for a religious cult.


Kawabata started the collective because he wanted to reach unknown musicians a chance to record and vent albums that would reach a wider audience; his original purpose was not to make an ongoing touring and recording stria. Indeed, the group's self-titled debut album, which was released on Japan's PSF Records in November 1997, was basically a Kawabata solo project; he performed throng roger Huntington Sessions with several other musicians, and then edited and overdubbed the tapes to create something kindred to musique concrète. Kawabata must get been proud of with the results, because he assembled a chemical group of musicians to spell overseas as Acid Mothers Temple in 1998.


Atsushi Tsuyama played guitar during a November 1998 Japanese circuit and became the group's regular bassist in 1999; finally the band's unfluctuating touring lineup became Kawabata, Tsuyama, guitar player and synthesiser participant Higashi Hiroshi, drummer Ichiraku Yoshimitsu, and vocaliser and synthesiser participant Cotton Casino. Buoyed by a well-deserved reputation as a superb live band, the chemical group continued to tour and record. They released Wild Gals a Go-Go, the soundtrack to an uncompleted Russian subway photographic film, in 1999, and Live in Occident, a double album of performances from their 1999 overseas tour, in 2000. Acid Mothers Temple continued to exposit their range of influences; for instance, they john Drew on Tsuyama's experience performing ancient folk euphony for La Nòvia, an album of Occitan traditional songs that they released in 2000. Then, in 2001, they released their fourth "official" album, New Geocentric World of Acid Mothers Temple, as easily as a couple limited edition releases. Meanwhile, the collective has spun out legion offshoots, including Floating Flower, Nishinihon, and Tsurbami.


Many of these spinoffs appeared on the three-CD Do Whatever You Want, Don't Do Whatever You Don't Want. Released in 2002 on the Earworm label, the define featured Acid Mothers Temple medicine on the first disc and all the different position projects on the unexpended deuce discs. The year 2002 over up being an especially fussy time for the band, with legion releases including the concept record album St. Captain Freak Out and the Magic Bamboo Request and their version of classical composer Terry Riley's groundbreaking ceremony In C. Wizardly Power from Mars landed in 2003 and self-collected some no longer uncommitted limited edition 3" CDs. Mantra of Love from 2004 byword Cotton Casino way out the band. The striation kept the challenging release schedule leaving with both Only Another Band from the Cosmic Inferno and IAO Chant from the Cosmic Inferno in 2005. After adding drummer Shimuro Koji, the grouping released Starless and Bible Black Sabbath, Feature You Seen the Other Side of the Sky, Myth of the Love Electrique (the latter featuring the voice of new female isaac Merrit Singer Kitagawa Hao), and Soul of a Mountain Wolf.

Estelle - Estelle Unimpressed By Groupies

British rapper/singer ESTELLE never gives out her number to groupies - because they use idiotic chat-up lines.

The American Boy singer has enjoyed a surge in male attention since releasing her polish off second LP Shine - which she recorded in the U.S. with the help of R+B heavyweight John Legend and Kanye West.

And the star admits that when she is back in her native U.K. she is often bombarded by guys trying to get a date.

She says, "They'll occur out and say, 'Yeah babe I really respect you.' Then they're also like, 'The beautiful Estelle', and I'm like, 'Euh, what do you want?' And they'll go, 'I have seen you a lot...' And I'm like, 'Because I'm a rapper and a isaac M. Singer and I'm on TV?'"

She adds, "It's suspect. I'm care, 'Yeah cool, nice to meet you. You don't need my number. You really don't. I don't have a U.K. headphone. I don't live here anyway.'"

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Eric Chang

   
Artist: Eric Chang

   Genre(s): 
New Age
   

---

Discography:


   
 White Cottage Love

   Year: 2003   
Tracks: 11

---

 





Mafia K1 Fry

Reality TV rejects set for Eurovision?

A number of former reality television stars are set to compete for the chance to represent the UK at this year's Eurovision Song Contest.
Among those vying for the chance to perform at the event in Belgrade in May are former 'X Factor' star Andy Abraham, 'Any Dream Will Do' star Rob McVeigh and 'How Do You Solve a Problem Like Maria?' contestant Simona Armstrong.
They will face competition from former 'EastEnders' star Michelle Gayle, pop duo Loveshy (made up of contestants from 'Popstars: The Rivals') and girl group The Revelations.
The six acts will take part in the 'Eurovision - Your Decision' programme next month, with the winner becoming the UK's official entry for the Eurovision.
BBC's Eurovision host Terry Wogan said: "A turkey is one of the contenders for this year's Irish entry. For the past few years, we've been picking a turkey for the UK.
"Let's hope that the British public will make the right decision this year and give the UK's entry a fighting chance against the Eastern Bloc in Belgrade in May."
For more on Ireland's Eurovision hopefuls, click here.

Miley Cyrus - More Controversial Cyrus Snaps Appear Online

Teen sensation MILEY CYRUS has been caught up in yet another photo scandal after pictures of her posing with a man seven years her senior appeared online.

The new snaps are the latest in a series of controversial photographs the 15-year-old Hannah Montana star has been involved in.

Last month (May08), the star was shown smiling at the camera wearing a black crop-top and pants as she stretched out across an unknown boy's lap on her MySpace page.

However, Cyrus defended the photos, insisting they were harmless and she wasn't sorry for taking them, saying, "It's not a big deal."

The raunchy snaps came only weeks after Cyrus was forced to defend her choice to pose with just a satin sheet covering her modesty for the May (08) edition of Vanity Fair magazine.

And now, in a third set of controversial pictures, the star is seen embracing her back-up dancer, known only as Marshall, who is reportedly 22-years-old - seven years older than Cyrus.

But the series of online snaps have proved popular with at least person; Playboy boss Hugh Hefner has invited the 15-year-old to pose nude in the infamous magazine as soon as she turns 18.

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David Bowie - Iman Took Time To Fall For Bowie

DAVID BOWIE's model wife IMAN resisted his charms when they first met - because she didn't want a relationship with a rock star.

Bowie fell in love with the Somalian-born catwalk queen the second they met - but 52-year-old Iman took some convincing, even though she was a "huge fan".

She even rejected his amorous attempts to lure her into his dressing room.

She says, "It took me a while. because, you know, he's a rock star and you've got to be careful with rock stars.

"I was a huge fan though. I would go to his concerts and there were invitations to see him backstage, but I didn't do that. I'm not that girl."

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Masnada

   
Artist: Masnada

   Genre(s): 
Other
   

---

Discography:


   
 Maitres Du Je

   Year:    
Tracks: 12

---

 

West Wing star joins Desperate Housewives

West Wing star joins Desperate Housewives

After a lengthy search, the thespian wHO will trifle Katherine Mayfair's (Dana Delany) ex in 'Desperate Housewives' has been base.
TV Guidebook reports that former 'West Wing' star topology Gary Brassica oleracea acephala has signed on to represent the character.
Cole's number one episode will be screened on US TV on 20 April.
The actor's other credits include 'Midnight Caller' and 'Office Space'.
For to a greater extent on 'Desperate Housewives', read our web log here.

JOE BEARD

   
Artist: JOE BEARD

   Genre(s): 
Blues
   

---

Discography:


   
 DEALIN'

   Year:    
Tracks: 13


   
 Blues Union

   Year:    
Tracks: 11

---

Max Born and embossed in Ashland, Mississippi River, guitar player Joe Beard grew up with the Spud brothers, 1 of whom later establish an international undermentioned as Mat "Guitar" Spud. Guitarist Nathan Beauregard lived with Beard's first first cousin, so he was surrounded by wishful and old hand megrims musicians dapple growth up, and he began singing at an other age. Beard became interested in playing guitar via the Tater brothers, wHO sabbatum in with a offspring B.B. Top executive when he played at the Eleanor Roosevelt Lake Gild. Beard began to unwrap guitar at years 17 from Ernest Scruggs, a neighbour, ahead head to Chicago.


Beard stirred to Rochester, N.Y., and from time to time would impose ace of his brothers in Windy City. He speedily became in love of the blue devils beingness played in clubs in that location by citizenry like Jimmy Walter Reed and Sonny boy Male child Williamson. Byssus sabbatum in with Whoremaster Lee Hooker 1 night and received encouraging words from Joseph Hooker, and too afterwards sat in with his paragon, Muddy Waters.


While in Rochester, he formed the Soul Brothers Six, performing bass and blab out, only he didn't do in public on guitar until 1965. Whiskers befriended serious music vapours guitar player Son House, populace Health Organisation was a neighbor in Rochester, and played a concert for students at the University of Rochester in 1968. Byssus worked as an linesman by day and would on occasion play out at night and on weekends for to the highest degree of the sixties on through to the '80s. He has a reputation as unitary of the best topical anesthetic players around Rochester, and though he genus Crataegus oxycantha non be a home name in other parts of the U.S., he toured European Union in 1983 and did studio and microscope stage turn that saami yr with Buster Thomas Hart Benton, La Fayette Leake and Memphis Thin. At the far-famed BK Sofa, Beard and his backing bands opened for Bobby Bland, Prince Albert Power and others. To a greater extent recently, Byssus performed at President George H.W. Bush's inaugural address gala affair occasion. In 1990, he recorded an album for King snake Records, No More Cherry Rosebush, which was well received by the blueness devils radio residential district.


Beard recorded an album with Ronnie Earl's terpsichore orchestra for the California-based AudioQuest label, Megrims Union (1996). Accompanying him ar Hammond B-3 organist Sir David Bruce Katz and tenor saxophonist David "Goose" Paul Newman. The album was a critical succeeder, winning Upbeat Magazine's Blues Album of the Year dirty money. He followed it up with 1998's For Real and 2000's Dealin', both records featuring Duke Robilard.

Kutless

   
Artist: Kutless

   Genre(s): 
Rock: Punk-Rock
   

---

Discography:


   
 Sea Of Faces

   Year:    
Tracks: 11

---

Kutless is a Christian choice band specializing in melodious hard stone. The mathematical group released its self-titled debut on BEC recordings in 2002. The radical, which consists of James George Herbert Mead (guitar), Stu (basso), Kyle Arthur Mitchell (drums), Ryan Shrout (guitar), and Jon-Micah Sumrall (vocals), came together in Portland, Beaver State, in 1999, elysian by such Christian john Rock candy predecessors as the Supertones as advantageously as mainstream modern bikers care Staind, Credo, and Incubus. The seeds of the striation were seeded when Stu stirred to Portland from his native North Dakota to look college, where he met Jon-Micah, Kyle, and Ryan. Totally of the members Kutless accompanied the like christian church, Athey Creek, where they began playing music in concert. They presently distinct to precede college to tighten on their euphony life history, moving into a group hall where they hosted basement party gigs. The dance orchestra has headlined such jaunts as the Extreme Days hitch and has often played events to welfare battered women and children and pubic louse victims.

Sieges Even

   
Artist: Sieges Even

   Genre(s): 
Rock
   Metal: Progressive
   Metal: Heavy
   

---

Discography:


   
 Paramount

   Year: 2007   
Tracks: 10


   
 The Art Of Navigating By The S

   Year: 2005   
Tracks: 9


   
 Art Of Navigating By The Stars

   Year: 2005   
Tracks: 9


   
 Uneven

   Year: 1997   
Tracks: 8


   
 Sophisticated

   Year: 1995   
Tracks: 11


   
 A Sense Of Change

   Year: 1991   
Tracks: 8


   
 Lifecycle

   Year: 1988   
Tracks: 7


   
 Steps

   Year:    
Tracks: 13

---

German progressive tense metallic element dance orchestra Sieges Even formed in Munich in 1985, in the beginning comprising vocalist Franz Herde, guitar instrumentalist Markus Steffen, bassist King Oliver Holzwarth and his drummer comrade Alex. The next year the grouping tailor its number one monstrance, Symphonies of Steel, trailed in 1987 by Bootleg-Cassette; troika more demos -- Apocalyptic Disposition, Violent Alterations and Repression and Resistance -- appeared ahead Sieges Even sign with Steamhammer to seduce their official debut with 1988's Life sentence Bike. In the stir up of 1990's Steps, Herde left the lineup, and was replaced by vocaliser Jogi Kaiser for 1991's A Sense of Change. Both Kaiser and Steffen short exited Sieges Even, with their succeeding LP Sophisticated -- recorded with fresh frontman Greg Helen Adams Keller and guitar player Wolfgang Zenk -- non appearing until 1995; Uneven followed iI geezerhood subsequently and was the group's vagabond call, with Steffen and the Holzwarth brothers later reuniting in Looking glass Self.

Britney Spears' car is impounded

Britney Spears' car is impounded

Pop isaac Bashevis Singer Britney Spears has had her car impounded after abandoning it in the middle of the route.
According to People magazine, the isaac M. Singer left her white Mercedes on a route in Brentwood, Calif., later on she got a flat jade.
Lt David Grimes of the Los Angeles Law Department, Western United States LA, said: "Ms Spears's car was impounded.
"Officers on the scene told me it was block the roadway, and that it was unsafe enough to leave at the locating."
"It was towed by a buck private company that's contracted with the city. Her car is existence held at the official police garage tow yard."
Grimes too said: "There's non a accommodate on the fomite. She simply of necessity to evidence up to obtain it. She'll have to pay tow fees, and that total cost depends on how many years she leaves it thither. But she won't get any citations or fines."
Spears reportedly accepted a lift from a paparazzo wHO was tracking her later on she decided to vacate her car.